产品货号：
LA10349
中文名称：
Z-IETD-FMK
英文名称：
Z-IETD-FMK
产品规格：
1mg|5mg
发货周期：
1～3天
产品价格：
询价
Z-IETD-FMK是一种特异性Caspase-8抑制剂。
相关搜索：Z-IETD-FMK，Caspase-8抑制剂，210344-98-2
| CAS号 | 210344-98-2 |
| 分子量 | 654.68 |
| 化学式 | C30H43FN4O11 |
| 纯度 | >98% |
| 稳定性 | 3 years -20℃ powder；2 years -80℃ in solvent |
| 溶解性 | DMSO:91mg/mL (138.99mM)；Water:<1mg/mL难溶或者不溶；Ethanol:<1mg/mL难溶或者不溶 |
| 产品描述 | Z-IETD-FMK是一种特异性Caspase-8抑制剂。 |
| 靶点 | Caspase-8 |
| 体外研究 | Z-IETD-FMK,which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP,prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli.Z-IETD-FMK (50μM) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3.Inhibition of caspase-8 by Z-IETD-FMK affects the generation of activated/memory T cells and T cell cytokine production,and decreases NF-kappaB responses to TCR:CD3 engagement in T cell cultures. |
| 体内研究 | In vivo,inhibition of caspase-8 by Z-IETD-FMK reduces memory/activated CD4 and CD8 T cells,and increases susceptibility to T.cruzi infection.Z-IETD-FMK promotes neuronal survival and regeneration of injured retinal ganglion cells after CNS injuries |
相关搜索：Z-IETD-FMK，Caspase-8抑制剂，210344-98-2